Cherubism: clinicopathologic features

Skeletal Radiol. 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530.

Abstract

A case of cherubism in 6-year-old boy is reported. He presented with bilateral symmetrical enlargement of the jaw in addition to medially dislocated premature teeth, narrow V-shaped palatal vault, and mild upward turning of the eyes. Radiographs showed multiloculated osteolysis in both the mandible and maxilla. Histology revealed a non-neoplastic fibrous lesion, rich in multinucleated giant cells, consistent with giant-cell reparative granuloma. Since the original description of cherubism, various histologic interpretations have been proposed, particularly that of fibrous dysplasia. However, it should be emphasized that cherubism is a disease histologically indistinguishable from giant-cell reparative granuloma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Cherubism / diagnosis
  • Cherubism / etiology*
  • Cherubism / surgery
  • Child
  • Diagnosis, Differential
  • Follow-Up Studies
  • Granuloma, Giant Cell / complications*
  • Granuloma, Giant Cell / diagnosis
  • Granuloma, Giant Cell / surgery
  • Humans
  • Male
  • Mandible* / diagnostic imaging
  • Mandible* / pathology
  • Mandible* / surgery
  • Maxilla* / diagnostic imaging
  • Maxilla* / pathology
  • Maxilla* / surgery
  • Radiography, Panoramic
  • Tomography, X-Ray Computed