Do HPV-negative cervical carcinomas exist?--revisited

J Pathol. 1999 Sep;189(1):1-3. doi: 10.1002/(SICI)1096-9896(199909)189:1<1::AID-PATH432>3.0.CO;2-P.


There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening.

Publication types

  • Comment
  • Editorial

MeSH terms

  • DNA, Viral / analysis*
  • Female
  • Humans
  • In Situ Hybridization
  • Papillomaviridae / genetics*
  • Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms / diagnosis
  • Uterine Cervical Neoplasms / virology*
  • Vaginal Smears


  • DNA, Viral