Insulin-like growth factors and prostate cancer

Cancer Metastasis Rev. 1998-1999;17(4):383-90. doi: 10.1023/a:1006154108619.


Converging data from epidemiological and biological research implicate insulin-like growth factor (IGF) physiology in the regulation of prostate epithelial cell proliferation and in the pathophysiology of prostate cancer. This review (1) outlines elements of IGF physiology, (2) reviews recent evidence that circulating IGF-I level is related to risk of prostate cancer, (3) provides a hypothesis concerning the biological basis for the relationship between IGF-I level and risk of prostate cancer, (4) discusses IGF-I physiology in the context of neoplastic progression of prostate cancer, and (5) discusses clinical implications of these lines of research with respect to prevention and treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / metabolism
  • Insulin-Like Growth Factor Binding Protein 3 / physiology
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Like Growth Factor I / physiology
  • Insulin-Like Growth Factor II / metabolism
  • Insulin-Like Growth Factor II / physiology
  • Male
  • Mice
  • Prostatic Neoplasms / blood*
  • Prostatic Neoplasms / prevention & control
  • Prostatic Neoplasms / therapy
  • Risk Factors
  • Somatomedins / metabolism*
  • Somatomedins / physiology*


  • Insulin-Like Growth Factor Binding Protein 3
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II