Mechanistic concepts in androgen-dependence of prostate cancer

Cancer Metastasis Rev. 1998-1999;17(4):421-7. doi: 10.1023/a:1006141806801.

Abstract

Androgen blockade is the mainstay of therapy in the clinical management of advanced prostate cancer. Recent progress on two fronts--the development of newer xenograft and transgenic models and a greater understanding of nuclear receptor signaling--has provided new insight into mechanisms of androgen-dependence in prostate cancer. This review centers on the concept that perturbations in androgen receptor signaling are likely to occur early in prostate cancer and play a critical role in progression to end stage hormone-refractory disease.

Publication types

  • Review

MeSH terms

  • Androgens / metabolism*
  • Androgens / physiology
  • Apoptosis
  • Cell Division / physiology
  • Cell Survival / physiology
  • Humans
  • Male
  • Prostatic Neoplasms / classification
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology
  • Receptors, Androgen / metabolism*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Signal Transduction / physiology
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism

Substances

  • Androgens
  • Receptors, Androgen
  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • Transcription Factors