Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants

Int J Oral Maxillofac Implants. 1999 Jul-Aug;14(4):529-35.


This article presents preliminary clinical evidence of the beneficial effect of the use of plasma rich in growth factors of autologous origin. The plasma is obtained from the individual patient by plasmapheresis. The macroscopic and microscopic results obtained with bone regeneration using this technique, which uses no membrane or barrier, can be observed. The incorporation of these concepts can introduce several advantages, including the enhancement and acceleration of bone regeneration and more rapid and predictable soft tissue healing.

Publication types

  • Case Reports
  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alveolar Process / drug effects*
  • Alveolar Process / pathology
  • Bone Regeneration / drug effects
  • Bone Transplantation
  • Dental Implantation, Endosseous*
  • Female
  • Growth Substances / blood
  • Growth Substances / therapeutic use*
  • Humans
  • Lymphotoxin-alpha / therapeutic use
  • Male
  • Middle Aged
  • Periodontal Diseases / surgery
  • Plasmapheresis
  • Platelet-Derived Growth Factor / therapeutic use
  • Tooth Extraction
  • Tooth Fractures / surgery
  • Tooth Socket / drug effects*
  • Tooth Socket / pathology
  • Wound Healing / drug effects


  • Growth Substances
  • Lymphotoxin-alpha
  • Platelet-Derived Growth Factor