Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease

Neurosci Lett. 1999 Jul 16;269(3):173-7. doi: 10.1016/s0304-3940(99)00421-8.

Abstract

In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha2-Macroglobin (A2M). There were 196 AD and 180 normal controls (N), which were age- and sex-matched. APOE epsilon4 alleles were significantly increased in AD vs. N (chi2 = 33.3, P < 0.000001). However, neither the -491 A/T (chi2 = 1.13, P = 0.29) nor A2M (chi2 = 0.18, P = 0.67) polymorphism was associated with AD risk, suggesting that these polymorphisms do not represent risk factors for AD in the Chinese population.

MeSH terms

  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / physiopathology*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics*
  • Asian Continental Ancestry Group / genetics*
  • China / ethnology
  • Exons
  • Female
  • Genetic Carrier Screening
  • Genotype
  • Hong Kong
  • Humans
  • Male
  • Odds Ratio
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic*
  • Reference Values
  • Sequence Deletion
  • alpha-Macroglobulins / genetics*

Substances

  • Apolipoprotein E4
  • Apolipoproteins E
  • alpha-Macroglobulins