In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites

Planta Med. 1999 Jun;65(5):442-3. doi: 10.1055/s-2006-960805.

Abstract

The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobacter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC was 10-20 micrograms/ml. However, these active compounds against HP did nearly not inhibit the urease activity of HP.

Publication types

  • Letter

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Ulcer Agents / pharmacology
  • Flavanones*
  • Flavonoids / pharmacology*
  • Gastric Mucosa / microbiology*
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / growth & development
  • Helicobacter pylori / isolation & purification
  • Hesperidin / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Phenols / pharmacology*
  • Pyloric Antrum

Substances

  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Flavanones
  • Flavonoids
  • Phenols
  • Hesperidin
  • naringenin
  • diosmetin