Abstract
Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha1, and alpha2 of the Saccharomyces cerevisiae mating-type (MAT) locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like locus that is similar to the mating-type loci of other fungi. In addition to the transcriptional regulators a1, alpha1, and alpha2, the C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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1-Phosphatidylinositol 4-Kinase / genetics
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Amino Acid Sequence
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Candida albicans / chemistry
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Candida albicans / genetics*
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Candida albicans / physiology
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Gene Deletion
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Gene Expression Regulation, Fungal*
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Genes, Fungal*
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Genes, Mating Type, Fungal*
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Homeodomain Proteins / chemistry
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / metabolism
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Introns
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Molecular Sequence Data
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Open Reading Frames
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Operator Regions, Genetic
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Polynucleotide Adenylyltransferase / genetics
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Receptors, Steroid / genetics
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Recombination, Genetic
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Repressor Proteins / chemistry
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism
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Saccharomyces cerevisiae / chemistry
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins*
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Transcription, Genetic
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Transformation, Genetic
Substances
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Homeodomain Proteins
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MATA1 protein, S cerevisiae
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MATA2 protein, S cerevisiae
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Receptors, Steroid
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Repressor Proteins
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Saccharomyces cerevisiae Proteins
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oxysterol binding protein
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1-Phosphatidylinositol 4-Kinase
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PIK1 protein, S cerevisiae
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Polynucleotide Adenylyltransferase
Associated data
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GENBANK/AF167162
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GENBANK/AF167163