Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans

Science. 1999 Aug 20;285(5431):1271-5. doi: 10.1126/science.285.5431.1271.


Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha1, and alpha2 of the Saccharomyces cerevisiae mating-type (MAT) locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like locus that is similar to the mating-type loci of other fungi. In addition to the transcriptional regulators a1, alpha1, and alpha2, the C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 1-Phosphatidylinositol 4-Kinase / genetics
  • Amino Acid Sequence
  • Candida albicans / chemistry
  • Candida albicans / genetics*
  • Candida albicans / physiology
  • Gene Deletion
  • Gene Expression Regulation, Fungal*
  • Genes, Fungal*
  • Genes, Mating Type, Fungal*
  • Homeodomain Proteins / chemistry
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism
  • Introns
  • Molecular Sequence Data
  • Open Reading Frames
  • Operator Regions, Genetic
  • Polynucleotide Adenylyltransferase / genetics
  • Receptors, Steroid / genetics
  • Recombination, Genetic
  • Repressor Proteins / chemistry
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins*
  • Transcription, Genetic
  • Transformation, Genetic


  • Homeodomain Proteins
  • MATA1 protein, S cerevisiae
  • MATA2 protein, S cerevisiae
  • Receptors, Steroid
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • oxysterol binding protein
  • 1-Phosphatidylinositol 4-Kinase
  • PIK1 protein, S cerevisiae
  • Polynucleotide Adenylyltransferase

Associated data

  • GENBANK/AF167162
  • GENBANK/AF167163