Mechanism of GnRH receptor signaling: from the membrane to the nucleus

Ann Endocrinol (Paris). 1999 Jul;60(2):79-88.


The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase C beta. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Cell Nucleus / metabolism*
  • GTP-Binding Proteins / physiology
  • Gonadotropin-Releasing Hormone / metabolism
  • Humans
  • Phospholipases / metabolism
  • Protein Kinases / metabolism
  • Receptors, LHRH / chemistry
  • Receptors, LHRH / physiology*
  • Signal Transduction*


  • Receptors, LHRH
  • Gonadotropin-Releasing Hormone
  • Protein Kinases
  • Phospholipases
  • GTP-Binding Proteins