Antibiotic hydrogel coated Foley catheters for prevention of urinary tract infection in a rabbit model

J Urol. 1999 Sep;162(3 Pt 1):883-7. doi: 10.1097/00005392-199909010-00084.

Abstract

Purpose: We developed an antibiotic liposome (ciprofloxacin liposome) containing hydrogel for external coating of silicone Foley catheters and evaluated its efficacy in a rabbit model. Our goal was to create a catheter that would hinder the development of catheter associated nosocomial urinary tract infections.

Materials and methods: We inserted either an untreated, liposomal hydrogel coated or a liposome hydrogel with ciprofloxacin coated 10F silicone Foley catheter into New Zealand White rabbits. We challenged the system with 5x10(6) virulent Escherichia coli at the urethral meatus twice daily for 3 days. Urine cultures were evaluated twice daily for 7 days. When urine cultures became positive, the rabbits were sacrificed and urine, urethral catheter and urethral tissue were cultured.

Results: The time to bacteriuria detection in 50% of the specimens was double for hydrogel with ciprofloxacin coated catheters versus untreated and hydrogel coated catheters. A significant (p = 0.04) improvement in average time to positive urine culture from 3.5 to 5.3 days and a 30% decrease in the bacteriuria rate for hydrogel with ciprofloxacin coated catheters were noted compared to untreated catheters.

Conclusions: A significant benefit was realized by coating the extraluminal catheter surface with a ciprofloxacin liposome impregnated hydrogel. We believe this procedure will provide a significant clinical advantage, while reducing health care costs substantially.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Infective Agents / administration & dosage*
  • Ciprofloxacin / administration & dosage*
  • Drug Carriers
  • Hydrogel, Polyethylene Glycol Dimethacrylate / administration & dosage*
  • Liposomes
  • Male
  • Rabbits
  • Urinary Catheterization*
  • Urinary Tract Infections / prevention & control*

Substances

  • Anti-Infective Agents
  • Drug Carriers
  • Liposomes
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Ciprofloxacin