Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

Curr Opin Microbiol. 1999 Aug;2(4):403-9. doi: 10.1016/s1369-5274(99)80071-x.


A general association of human and primate lymphotropic herpesviruses (gamma-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human gamma-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is providing insights into viral and host factors involved in the establishment and control of chronic gamma-herpesvirus infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Disease Models, Animal
  • Gammaherpesvirinae / genetics*
  • Gammaherpesvirinae / physiology
  • Herpesviridae Infections / immunology*
  • Herpesviridae Infections / virology
  • Humans
  • Mice
  • Virus Latency / genetics