Antigenic variation in Plasmodium falciparum: mechanisms and consequences

Curr Opin Microbiol. 1999 Aug;2(4):420-5. doi: 10.1016/S1369-5274(99)80074-5.


In the past year, the major advances in malaria antigenic variation have been concerned with the transcription and switching of variant antigen genes, and the functional expression of regions of the major variant antigen. Also, new variant gene families have been discovered as a result of the Malaria Genome Project.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigenic Variation / genetics*
  • Humans
  • Malaria, Falciparum / immunology*
  • Malaria, Falciparum / parasitology
  • Plasmodium falciparum / genetics*
  • Plasmodium falciparum / immunology