Adhesins in Candida Albicans

Curr Opin Microbiol. 1999 Aug;2(4):353-7. doi: 10.1016/S1369-5274(99)80062-9.

Abstract

The adherent properties of Candida albicans blastoconidia and germ tubes have long been appreciated, but little is known about the mechanisms responsible for adherence. Recently, three genes, ALA1, ALS1 and HWP1, encoding proteins with adherent properties and motifs consistent with linkage to the beta-1, 6-glucan of C. albicans cell walls have provided insight into the topology of protein adhesins. Hwp1, a developmentally regulated adhesin of germ tubes and hyphae, attaches to buccal epithelial cells by an unconventional, transglutaminase-mediated mechanism of adhesion.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Candida albicans / genetics*
  • Cell Adhesion / genetics
  • Cell Adhesion Molecules*
  • Fungal Proteins / genetics*
  • Membrane Glycoproteins / genetics
  • Molecular Sequence Data

Substances

  • ALA1 protein, Candida albicans
  • ALS1 protein, Candida albicans
  • Cell Adhesion Molecules
  • Fungal Proteins
  • HWP1 protein, Candida albicans
  • Membrane Glycoproteins