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Review
, 2 (4), 438-43

Inhibition of Host Cell Signal Transduction by Leishmania: Observations Relevant to the Selective Impairment of IL-12 Responses

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Review

Inhibition of Host Cell Signal Transduction by Leishmania: Observations Relevant to the Selective Impairment of IL-12 Responses

M A McDowell et al. Curr Opin Microbiol.

Abstract

Leishmania parasites are able to delay the onset of cell-mediated immunity by selectively impairing the ability of infected macrophages to produce interleukin (IL)-12. Leishmania infection arrests the JAK/STAT-mediated signal transduction involved in activation of the IL-12 p40 promoter; the phosphorylation defects may be initiated by ligation of the phagocyte receptors used by these organisms to gain entry into the host cell.

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