Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

Cancer Genet Cytogenet. 1999 Aug;113(1):70-2. doi: 10.1016/s0165-4608(99)00007-2.


We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16) (p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / genetics*
  • Blotting, Southern
  • Chromosome Aberrations / genetics*
  • Chromosome Disorders
  • Chromosome Inversion*
  • Chromosomes, Human, Pair 8*
  • Histone Acetyltransferases
  • Humans
  • Karyotyping
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Models, Genetic
  • Molecular Sequence Data
  • Nuclear Receptor Coactivator 2
  • Transcription Factors / genetics*


  • NCOA2 protein, human
  • Nuclear Receptor Coactivator 2
  • Transcription Factors
  • Acetyltransferases
  • Histone Acetyltransferases
  • KAT6A protein, human

Associated data

  • GENBANK/U47742