Inhibitory effect of povidone-iodine for the antigen expression of human cytomegalovirus

In Vivo. May-Jun 1999;13(3):239-41.

Abstract

Anti-human cytomegalovirus (HCMV) properties of povidone-iodine (PVP-I) were evaluated in vitro. The effect of PVP-I was evaluated by indirect immunofluorescence assay on HCMV-infected MRC-5 cells. Percentages of fluorescent cells positive for HCMV immediate early and early antigens in cultures inoculated with AD 169 treated with PVP-I at various concentrations and reaction times were compared with the number of fluorescent cells in the controls inoculated with the virus alone. PVP-I was found to exert some inhibitory effect at a concentration of 0.5% and complete inhibition at a concentration of 7.5% on the infection of MRC-5 cells by HCMV AD 169 strain. Entirely new approaches to the prevention of HCMV infections in infants are necessary. The adequate use of PVP-I as a disinfectant may reduce the transmission of HCMV.

MeSH terms

  • Anti-Infective Agents, Local / pharmacology*
  • Antigens, Viral / biosynthesis*
  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • Cytomegalovirus / drug effects
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / immunology*
  • Cytomegalovirus Infections / prevention & control*
  • Embryo, Mammalian
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Lung / cytology
  • Lung / virology
  • Povidone-Iodine / pharmacology*

Substances

  • Anti-Infective Agents, Local
  • Antigens, Viral
  • Antiviral Agents
  • Povidone-Iodine