Abstract
Aims:
We report a case study to highlight the occurrence of glioblastoma multiforme in an ovarian teratoma.
Methods and results:
A 10-year-old girl presented with a left frontal lobe primitive neuroectodermal tumour which was successfully treated. After 6 uneventful years, she developed glioblastoma multiforme located posterior to the site of the initial tumour. Six years later, she presented with a mature cystic teratoma containing glioblastoma multiforme.
Conclusions:
Glioblastoma in an ovarian teratoma is an exceptional event, which might have an initial clinical presentation as a metastatic brain tumour. Alternatively, recurring glial tumours may occur in a genetically predisposed person; the role of radiation and chemotherapy in this context remains to be elucidated.
MeSH terms
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Biomarkers, Tumor / analysis
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Brain Neoplasms / chemistry
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Brain Neoplasms / pathology*
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Brain Neoplasms / therapy
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Child
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Female
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Frontal Lobe / pathology*
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Glioblastoma / chemistry
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Glioblastoma / pathology*
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Glioblastoma / therapy
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Humans
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Immunoenzyme Techniques
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Neoplasm Recurrence, Local / chemistry
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / therapy
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Neoplasms, Second Primary / chemistry
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Neoplasms, Second Primary / pathology*
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Neoplasms, Second Primary / therapy
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Neuroectodermal Tumors, Primitive / chemistry
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Neuroectodermal Tumors, Primitive / pathology
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Neuroectodermal Tumors, Primitive / therapy
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Ovarian Neoplasms / chemistry
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Ovarian Neoplasms / pathology*
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Ovarian Neoplasms / therapy
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Teratoma / chemistry
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Teratoma / pathology*
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Teratoma / therapy