RNA-triggered gene silencing

Trends Genet. 1999 Sep;15(9):358-63. doi: 10.1016/s0168-9525(99)01818-1.


Double-stranded RNA (dsRNA) has recently been shown to trigger sequence-specific gene silencing in a wide variety of organisms, including nematodes, plants, trypanosomes, fruit flies and planaria; meanwhile an as yet uncharacterized RNA trigger has been shown to induce DNA methylation in several different plant systems. In addition to providing a surprisingly effective set of tools to interfere selectively with gene function, these observations are spurring new inquiries to understand RNA-triggered genetic-control mechanisms and their biological roles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Biological Evolution
  • Gene Expression
  • Immunity / genetics
  • Models, Genetic
  • Plants, Genetically Modified
  • RNA, Double-Stranded / genetics*


  • RNA, Double-Stranded