Administration of diminazene aceturate or imidocarb dipropionate for treatment of cytauxzoonosis in cats

J Am Vet Med Assoc. 1999 Aug 15;215(4):497-500, 482.

Abstract

Bobcats (Lynx rufus) are the reservoir hosts for Cytauxzoon felis, the causative agent of cytauxzoonosis. Cytauxzoonosis is a highly fatal tickborne blood protozoal disease of domestic and exotic cats. Treatment of clinically affected cats has generally been unrewarding. In our report, 6 of 7 cats had signs of illness and laboratory findings indicative of cytauxzoonosis and were successfully treated with 2 i.m. injections of diminazene aceturate or imidocarb dipropionate (2 mg/kg [0.9 mg/lb] of body weight, each). One cat died after the first injection of diminazene. Additional treatment with isotonic fluids i.v. and heparin s.c. were used as supportive care for dehydration and disseminated intravascular coagulation that were detected by laboratory testing between diminazene or imidocarb treatments. Atropine was effective in recovery and preventing adverse reactions associated with imidocarb treatment of 1 cat.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiprotozoal Agents / administration & dosage
  • Antiprotozoal Agents / therapeutic use*
  • Blood / parasitology
  • Blood Transfusion / veterinary
  • Body Temperature
  • Cat Diseases / drug therapy*
  • Cat Diseases / parasitology
  • Cats
  • Diminazene / administration & dosage
  • Diminazene / analogs & derivatives*
  • Diminazene / therapeutic use
  • Erythrocyte Count / veterinary
  • Hematocrit / veterinary
  • Hematologic Diseases / drug therapy
  • Hematologic Diseases / parasitology
  • Hematologic Diseases / veterinary*
  • Heparin / therapeutic use
  • Imidocarb / administration & dosage
  • Imidocarb / analogs & derivatives*
  • Imidocarb / therapeutic use
  • Injections, Intramuscular / veterinary
  • Isotonic Solutions / therapeutic use
  • Leukocyte Count / veterinary
  • Male
  • Piroplasmida* / drug effects
  • Protozoan Infections / drug therapy
  • Protozoan Infections, Animal*
  • Urinalysis / veterinary

Substances

  • Antiprotozoal Agents
  • Isotonic Solutions
  • Imidocarb
  • Heparin
  • diminazene aceturate
  • Diminazene
  • imidocarb dipropionate