Syndrome of inappropriate secretion of antidiuretic hormone in malignancy

Semin Oncol Nurs. 1999 Aug;15(3):160-7. doi: 10.1016/s0749-2081(99)80003-5.


Objectives: To provide a review of pathophysiology, epidemiology, signs and symptoms, diagnosis, treatment, and nursing management of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignancy.

Data sources: Research reports, review articles, and book chapters relevant to SIADH.

Conclusions: The principle cause of hyponatremia in malignancy is SIADH. Early recognition and prompt treatment can prevent serious neurologic sequelae. Antineoplastic therapy and methods to correct hyponatremia constitute effective treatment strategies.

Implications for nursing practice: Nurses play a major role in nursing assessment, appropriate interventions and symptom control, and promoting resolution of problems and optimal quality of life in patients with malignancy complicated by SIADH.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Carcinoma, Neuroendocrine / complications*
  • Carcinoma, Neuroendocrine / secondary
  • Carcinoma, Small Cell / pathology*
  • Fatal Outcome
  • Humans
  • Inappropriate ADH Syndrome / etiology
  • Inappropriate ADH Syndrome / nursing*
  • Lung Neoplasms / pathology*
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Oncology Nursing