Pathological evaluation of renal tumors in children: international society of pediatric oncology approach

Pediatr Dev Pathol. May-Jun 1998;1(3):243-8. doi: 10.1007/s100249900033.

Abstract

In the majority of European countries, children with renal tumors now enter the SIOP-93-01 Trial and Study. The objective of this Study is to refine methods of treatment especially in stage I patients. The role of institutional pathologists is important in this trial. There are new criteria for stages I and II, a new SIOP Working Classification of Renal Tumors of Childhood, and morphologic and prognostic similarities of pretreated and non-pretreated anaplastic cases. Specific problems encountered in assessing tumors treated with preoperative chemotherapy, administered to the majority of children over 6 months of age entering the SIOP Study, are discussed. The identification of a new low-risk group, the completely necrotic Wilms tumor, is outlined.

Publication types

  • Guideline
  • Multicenter Study
  • Practice Guideline

MeSH terms

  • Anaplasia / pathology
  • Child
  • Child, Preschool
  • France
  • Humans
  • Infant
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / therapy
  • Medical Oncology
  • Neoplasm Staging
  • Wilms Tumor / pathology
  • Wilms Tumor / therapy