New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies

Naunyn Schmiedebergs Arch Pharmacol. 1999 Jul;360(1):5-13. doi: 10.1007/s002109900030.


A huge number of receptors signals through heterotrimeric G-proteins to regulate a wide variety of physiological processes. The ability to modify G-protein expression in vivo provides a powerful new tool to analyze the function of G-protein-mediated signalling pathways. Genetic ablation of G-protein alpha-subunit genes is continuing to give new insights into the physiological roles of heterotrimeric G-proteins. This review highlights recent advances resulting from such genetic approaches to the study of G-protein-mediated signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Ataxia / blood
  • Ataxia / genetics
  • Brain / pathology
  • Brain / physiopathology
  • Cerebellum / physiopathology
  • GTP-Binding Protein alpha Subunits, Gi-Go / physiology
  • GTP-Binding Protein alpha Subunits, Gs / genetics
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / physiology*
  • Gene Deletion
  • Gene Dosage
  • Mice
  • Mice, Mutant Strains
  • Platelet Activation
  • Signal Transduction / physiology*


  • GTP-Binding Proteins
  • GTP-Binding Protein alpha Subunits, Gi-Go
  • GTP-Binding Protein alpha Subunits, Gs