ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

J Biol Chem. 1999 Sep 3;274(36):25555-63. doi: 10.1074/jbc.274.36.25555.


We report the primary structure of three novel, putative zinc metalloproteases designated ADAM-TS5, ADAM-TS6, and ADAM-TS7. All have a similar domain organization, comprising a preproregion, a reprolysin-type catalytic domain, a disintegrin-like domain, a thrombospondin type-1 (TS) module, a cysteine-rich domain, a spacer domain without cysteine residues, and a COOH-terminal TS module. These genes are differentially regulated during mouse embryogenesis and in adult tissues, with Adamts5 highly expressed in the peri-implantation period in embryo and trophoblast. These proteins are similar to four other cognate gene products, defining a distinct family of human reprolysin-like metalloproteases, the ADAM-TS family. The other members of the family are ADAM-TS1, an inflammation-induced gene, the procollagen I/II amino-propeptide processing enzyme (PCINP, ADAM-TS2), and proteins predicted by the KIAA0366 and KIAA0688 genes (ADAM-TS3 and ADAM-TS4). Individual ADAM-TS members differ in the number of COOH-terminal TS modules, and some have unique COOH-terminal domains. The ADAM-TS genes are dispersed in human and mouse genomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ADAM Proteins
  • ADAMTS Proteins
  • ADAMTS5 Protein
  • ADAMTS7 Protein
  • Amino Acid Sequence
  • Animals
  • Chromosome Mapping
  • Cloning, Molecular
  • Disintegrins*
  • Genome
  • Genome, Human*
  • Humans
  • Metalloendopeptidases / genetics*
  • Metalloendopeptidases / isolation & purification
  • Metalloendopeptidases / metabolism
  • Mice
  • Molecular Sequence Data
  • Organ Specificity
  • Sequence Alignment


  • Disintegrins
  • ADAM Proteins
  • ADAMTS Proteins
  • ADAMTS5 Protein
  • ADAMTS5 protein, human
  • ADAMTS7 Protein
  • ADAMTS7 protein, human
  • Adamts5 protein, mouse
  • Adamts6 protein, human
  • Metalloendopeptidases

Associated data

  • GENBANK/AF140673
  • GENBANK/AF140674
  • GENBANK/AF140675
  • GENBANK/AF141293