Expression of metalloproteinase-2 (gelatinase A) in labial salivary glands of patients with Sjögren's syndrome with HTLV-I infection

Clin Exp Rheumatol. Jul-Aug 1999;17(4):463-6.


Objective: To determine whether gelatinase A (MMP-2) plays a significant role in the pathogenesis of Sjögren's syndrome (SS) with or without HTLV-I infection.

Methods: We examined 24 patients with SS (14 HTLV-I-seropositive and 8 HTLV-I-seronegative). Labial salivary gland tissue samples were analysed immunohistochemically using anti-MMP-2 monoclonal antibodies.

Results: In normal salivary glands, MMP-2 expression was not detected. All biopsy samples of 8 SS patients with HTLV-I-associated myelopathy (HAM) and 3 of 6 HTLV-I-seropositive SS patients without manifestation of HAM stained positively for MMP-2. However, the other samples were negative for MMP-2.

Conclusion: Our study showed the MMP-2 expression in labial salivary glands of HTLV-I seropositive SS patients, especially in all SS patients with HAM. The presence of MMP-2 in the salivary glands of these patients suggests that it may play a role in cellular infiltration and destruction in salivary glands of SS.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Biopsy
  • Female
  • Gelatinases / analysis
  • Gelatinases / biosynthesis*
  • Gelatinases / immunology
  • Human T-lymphotropic virus 1*
  • Humans
  • Matrix Metalloproteinase 2
  • Metalloendopeptidases / analysis
  • Metalloendopeptidases / biosynthesis*
  • Metalloendopeptidases / immunology
  • Middle Aged
  • Paraparesis, Tropical Spastic / metabolism*
  • Paraparesis, Tropical Spastic / pathology
  • Salivary Glands, Minor / enzymology*
  • Salivary Glands, Minor / pathology
  • Salivary Glands, Minor / virology
  • Sjogren's Syndrome / metabolism*
  • Sjogren's Syndrome / pathology
  • Sjogren's Syndrome / virology*


  • Antibodies, Monoclonal
  • Gelatinases
  • Metalloendopeptidases
  • Matrix Metalloproteinase 2