Inhibitory effect of intestinal bacteria on spontaneous multiple polyps in the small intestine of gnotobiotic BALB/c mice

J Exp Clin Cancer Res. 1999 Jun;18(2):255-8.

Abstract

The incidence of multiple polyps and number of polyps per mouse were significantly lower in conventionalized (CVz), and chloroform-resistant bacteria (CRB)- or fusiform bacteria (FB)-associated mice than in germfree (GF) BALB/c mice. The concentration of fecal fatty acids was also higher in mice associated with either CRB or FB than in GF mice. The incidence of multiple polyps and number of polyps per mouse were significantly correlated with the concentration of fatty acids in the feces of CVz and CRB-GB mice. This study demonstrated that inhibition of multiple polyps in the small intestine of BALB/c mice was affected by the production of intestinal fatty acids.

MeSH terms

  • Animals
  • Fatty Acids / analysis
  • Feces / chemistry
  • Female
  • Germ-Free Life*
  • Intestinal Neoplasms / etiology*
  • Intestinal Neoplasms / metabolism
  • Intestinal Neoplasms / microbiology*
  • Intestinal Polyps / etiology*
  • Intestinal Polyps / metabolism
  • Intestinal Polyps / microbiology*
  • Intestine, Small / metabolism
  • Intestine, Small / microbiology*
  • Mice
  • Mice, Inbred BALB C
  • Neoplasms, Multiple Primary / etiology*
  • Neoplasms, Multiple Primary / metabolism
  • Neoplasms, Multiple Primary / microbiology*

Substances

  • Fatty Acids