Altered Lung Antioxidant Status in Patients With Mild Asthma

Lancet. 1999 Aug 7;354(9177):482-3. doi: 10.1016/S0140-6736(99)01812-7.

Abstract

Lung lining fluid ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) concentrations are low in patients with mild asthma even though blood levels are normal or increased. These findings, along with the presence of increased amounts of oxidised glutathione in their airways, indicate that patients with asthma are subject to increased oxidative stress.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / metabolism*
  • Ascorbic Acid / metabolism
  • Asthma / diagnosis*
  • Asthma / metabolism
  • Bronchoalveolar Lavage Fluid / chemistry
  • Chromatography, High Pressure Liquid
  • Glutathione / metabolism
  • Humans
  • Lung / metabolism*
  • Oxidation-Reduction
  • Reference Values
  • Vitamin E / metabolism

Substances

  • Antioxidants
  • Vitamin E
  • Glutathione
  • Ascorbic Acid