Endothelin receptor antagonists reduce the pressor effects of angiotensin II into the periaqueductal gray area of rats

Life Sci. 1999;65(9):PL95-9. doi: 10.1016/s0024-3205(99)00327-6.

Abstract

Injection of ANGII (0.01, 0.1 and 1 nmol/rat) into the periaqueductal gray (PAG) area significantly (P<0.01) increased, in a dose-dependent manner, the mean arterial blood pressure (MAP). The increases in blood pressure induced by ANGII (1 nmol; 37 +/- 4 mmHg, n=5) were greatly reduced (>85%) by pre-administration of the ET(A) receptor antagonist FR139317 (5 nmol/rat) to the PAG area, but were unaffected by the ET(B) receptor antagonist BQ-788 (5 nmol/rat). SB209670, non-selective ET(A)/ET(B) receptor antagonist, also reduced the effect induced by ANGII. These results suggest that endogenous endothelin-1, via an action on ET(A) receptors, may contribute to the pressor effects of ANGII within the PAG area of rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / pharmacology*
  • Animals
  • Azepines / pharmacology
  • Blood Pressure / drug effects*
  • Dose-Response Relationship, Drug
  • Endothelin Receptor Antagonists*
  • Endothelin-1 / physiology
  • Indans / pharmacology
  • Indoles / pharmacology
  • Male
  • Oligopeptides / pharmacology
  • Periaqueductal Gray / drug effects*
  • Piperidines / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Endothelin A
  • Receptor, Endothelin B
  • Receptors, Endothelin / physiology

Substances

  • Azepines
  • Endothelin Receptor Antagonists
  • Endothelin-1
  • Indans
  • Indoles
  • Oligopeptides
  • Piperidines
  • Receptor, Endothelin A
  • Receptor, Endothelin B
  • Receptors, Endothelin
  • 1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-
  • Angiotensin II
  • FR 139317
  • BQ 788