An amide of L-threo-gamma-hydroxyglutamic acid from Justicia ghiesbreghtiana

P Lorenz; F R Stermitz; L D Ismail

doi:10.1016/s0031-9422(99)00172-7

An amide of L-threo-gamma-hydroxyglutamic acid from Justicia ghiesbreghtiana

Phytochemistry. 1999 Sep;52(1):63-6. doi: 10.1016/s0031-9422(99)00172-7.

Authors

P Lorenz¹, F R Stermitz, L D Ismail

Affiliation

¹ Department of Chemistry, Colorado State University, Fort Collins 80523, USA.

PMID: 10466224
DOI: 10.1016/s0031-9422(99)00172-7

Abstract

A new amide of threo-gamma-hydroxyglutamic acid, justiciamide, was isolated from Justicia ghiesbreghtiana and shown to be (-)-N-(2-hydroxy-4,5-dimethoxyphenyl)-(2 S,4 S)-gamma-hydroxyglutamic acid. Justiciamide is the first amide of an uncommon amino acid found in this genus.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Glutamates / chemistry*
Glutamates / isolation & purification*
Glutamates / pharmacology
Microbial Sensitivity Tests
Molecular Structure
Plants / chemistry*
Spectrum Analysis

Substances

Glutamates
justiciamide
hydroxyglutamic acid

Grants and funding

GM49631/GM/NIGMS NIH HHS/United States