Protein folding in a specialized compartment: the endoplasmic reticulum

A Zapun; C A Jakob; D Y Thomas; J J Bergeron

doi:10.1016/s0969-2126(99)80112-9

Protein folding in a specialized compartment: the endoplasmic reticulum

Structure. 1999 Aug 15;7(8):R173-82. doi: 10.1016/s0969-2126(99)80112-9.

Authors

A Zapun¹, C A Jakob, D Y Thomas, J J Bergeron

Affiliation

¹ Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.

PMID: 10467145
DOI: 10.1016/s0969-2126(99)80112-9

Abstract

The endoplasmic reticulum ensures proper folding of secretory proteins. In this review, we summarize and discuss the functions of different classes of folding mediators in the secretory pathway and propose updated models of the quality control system.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Compartmentation
Endoplasmic Reticulum / metabolism*
Glycoproteins / metabolism
Lectins / metabolism
Peptidylprolyl Isomerase / metabolism
Protein Disulfide-Isomerases / metabolism
Protein Folding*

Substances

Glycoproteins
Lectins
Peptidylprolyl Isomerase
Protein Disulfide-Isomerases