Gluten-free diet decreases urinary peptide levels in children with celiac disease

J Pediatr Gastroenterol Nutr. 1999 Sep;29(3):282-5. doi: 10.1097/00005176-199909000-00008.


Background: Increased urine secretion of peptides has been found in celiac disease, probably resulting from increased intestinal uptake of peptides caused by damage to the small gut mucosa.

Methods: High-performance liquid chromatography of low-molecular-weight peptides in the urine was performed over 6 months, before and after a gluten-free diet was instituted in children who clinically improved while consuming the diet.

Results: A significant decrease of peptide levels was observed in children consuming the gluten-free diet. Certain peptide peaks thought to be gluten related decreased the most after the patients began the diet.

Conclusions: Because the peptides decrease in patients consuming a gluten-free diet, it is reasonable to conclude that such peptides have a mostly dietary origin.

MeSH terms

  • Adolescent
  • Celiac Disease / diet therapy*
  • Celiac Disease / urine*
  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Gliadin / urine
  • Glutens / administration & dosage*
  • Glutens / urine
  • Humans
  • Molecular Weight
  • Peptides / urine*


  • Peptides
  • Glutens
  • Gliadin