Histopathologic comparison of human coronary in-stent and post-balloon angioplasty restenotic tissue

Am J Cardiol. 1999 Aug 15;84(4):462-6, A9. doi: 10.1016/s0002-9149(99)00334-3.


Histomorphometric studies for smooth muscle cells, macrophages, tissue factor, collagen, and cell proliferation were performed on 20 atherectomy specimens from patients with in-stent restenosis and 20 specimens from patients with post-balloon PTCA restenosis. Smooth muscle cell content was larger and proliferation index was higher in in-stent restenotic tissue; macrophage, tissue factor, and collagen content were larger in post-balloon percutaneous transluminal coronary angioplasty restenotic tissue, suggesting a more cellular and proliferative response with less thrombogenic potential in human tissue from in-stent restenosis than tissue from post-balloon percutaneous transluminal coronary angioplasty restenosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / adverse effects*
  • Atherectomy, Coronary
  • Cell Division
  • Coronary Angiography
  • Coronary Vessels / diagnostic imaging
  • Coronary Vessels / pathology*
  • Extracellular Matrix / pathology
  • Female
  • Graft Occlusion, Vascular / diagnosis*
  • Graft Occlusion, Vascular / etiology
  • Graft Occlusion, Vascular / surgery
  • Humans
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular / diagnostic imaging
  • Muscle, Smooth, Vascular / pathology
  • Prosthesis Failure
  • Stents*
  • Ultrasonography, Interventional