Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53

Br J Cancer. 1999 Aug;80(11):1828-9. doi: 10.1038/sj.bjc.6690606.

Abstract

Homozygous arginine at codon 72 (HA72) of p53 was found in 22% of normal cervices and 30.0% of cervical cancers and no significant difference was detected between normal and cervical cancer with or without HPV 16/18. There was no correlation between HA72 and risk of cervical cancer in Chinese.

MeSH terms

  • Arginine*
  • Asian Continental Ancestry Group / genetics*
  • China / ethnology
  • Female
  • Genes, p53*
  • Homozygote*
  • Hong Kong / epidemiology
  • Humans
  • Incidence
  • Papillomaviridae / isolation & purification
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk Factors
  • Tumor Suppressor Protein p53 / genetics*
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / virology

Substances

  • Tumor Suppressor Protein p53
  • Arginine