Prognostic factors relating to survival in uterine endometrioid carcinoma

Int J Gynaecol Obstet. 1999 Aug;66(2):155-62. doi: 10.1016/s0020-7292(99)00067-3.


Objective: Epidemiologic and clinicohistopathologic prognostic factors of uterine endometrioid carcinomas were analyzed. The association of estrogen related factors, focused on adenomyosis in the prognosis of endometrioid carcinomas was also examined.

Methods: Risk factors of surgically treated 286 patients with endometrioid carcinoma (Stage I-III) were statistically analyzed.

Results: Overall a recurrence-free 5-year survival rate was 81% (Stage I, 94%, Stage II, 71% and Stage III, 40%). Significant prognostic factors were lymph node metastases (P = 0.0035) and serosal/parametrial invasion (P = 0.014) by multivariate analysis. Endometrioid carcinomas with co-existing adenomyosis tend to be associated with endometrial hyperplasia (P = 0.04, Fisher's exact test), diagnosed in less invasive status (myometrial invasion, P = 0.004 and serosal/parametrial invasion, P = 0.006) and therefore have a favorable prognosis (P = 0.01, log rank test).

Conclusions: A favorable prognosis of endometrioid carcinomas with co-existing estrogen related factors (adenomyosis and endometrial hyperplasia) was suggested.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Endometrioid / mortality*
  • Carcinoma, Endometrioid / pathology*
  • Carcinoma, Endometrioid / secondary
  • Endometriosis
  • Estrogens / metabolism
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Prognosis
  • Risk Factors
  • Survival Rate
  • Uterine Neoplasms / mortality*
  • Uterine Neoplasms / pathology*


  • Estrogens