Menstrual and reproductive factors for salivary gland cancer risk in women

Epidemiology. 1999 Sep;10(5):528-30.

Abstract

Several observations suggest that salivary gland cancer may be, in part, a hormonally dependent disease. We examined associations between hormonally mediated life events and salivary gland cancer risk in a population-based case-control study. Of 76 women diagnosed between 1989 and 1993, 63 (83%) were interviewed. Of 111 population controls, 83 (75%) were interviewed. Early menarche (OR = 4.1, 95% CI = 1.4-12.1) and nulliparity (OR = 2.6, 95% CI = 1.0-6.7) were associated with increased risk whereas late age at first full-term pregnancy (OR = 0.19, 95% CI = 0.3-1.2) and longer duration of oral contraceptive use (OR = 0.31, 95% CI = 0.10-1.0) were associated with diminished risk. These findings are consistent with a hormonal component in salivary gland cancer risk.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • California / epidemiology
  • Case-Control Studies
  • Climacteric
  • Female
  • Humans
  • Menarche
  • Menstrual Cycle
  • Middle Aged
  • Pregnancy
  • Reproductive History*
  • Risk Factors
  • Salivary Gland Neoplasms / epidemiology
  • Salivary Gland Neoplasms / etiology*
  • Statistics as Topic