Receptor signaling: when dimerization is not enough

Curr Biol. 1999 Jul 29-Aug 12;9(15):R568-71. doi: 10.1016/s0960-9822(99)80357-1.

Abstract

Activation of receptors that signal via tyrosine kinase domains has been thought to involve receptor dimerization and transphosphorylation of juxtaposed catalytic domains. Recent results suggest things might be more complex - specific intersubunit conformational changes within a dimer can also be important.

Publication types

  • Review

MeSH terms

  • Animals
  • Dimerization
  • Models, Molecular
  • Phosphorylation
  • Protein Conformation
  • Protein Structure, Quaternary
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Erythropoietin / chemistry
  • Receptors, Erythropoietin / metabolism
  • Signal Transduction

Substances

  • Receptors, Cell Surface
  • Receptors, Erythropoietin