Receptor signaling: when dimerization is not enough

Curr Biol. 1999 Jul 29-Aug 12;9(15):R568-71. doi: 10.1016/s0960-9822(99)80357-1.


Activation of receptors that signal via tyrosine kinase domains has been thought to involve receptor dimerization and transphosphorylation of juxtaposed catalytic domains. Recent results suggest things might be more complex - specific intersubunit conformational changes within a dimer can also be important.

Publication types

  • Review

MeSH terms

  • Animals
  • Dimerization
  • Models, Molecular
  • Phosphorylation
  • Protein Conformation
  • Protein Structure, Quaternary
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Erythropoietin / chemistry
  • Receptors, Erythropoietin / metabolism
  • Signal Transduction


  • Receptors, Cell Surface
  • Receptors, Erythropoietin