An overview of cyclophosphamide development and clinical applications

Curr Pharm Des. 1999 Aug;5(8):555-60.


In this overview of the pharmacology of the anticancer drug cyclophosphamide, a brief history of the development of this drug from the general class of nitrogen mustards is provided. The antitumor activity of cyclophosphamide and its isomer ifosfamide is discussed through considerations of metabolism, resistance, detoxification, and DNA cross-linking. Clinical uses in general chemotherapy, bone marrow transplantation and immunosuppression are presented. A review with 73 references.

Publication types

  • Historical Article
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antineoplastic Agents, Alkylating / history
  • Antineoplastic Agents, Alkylating / pharmacology
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Cyclophosphamide / history
  • Cyclophosphamide / pharmacology
  • Cyclophosphamide / therapeutic use*
  • History, 20th Century
  • Humans
  • Immunosuppressive Agents / history
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*


  • Antineoplastic Agents, Alkylating
  • Immunosuppressive Agents
  • Cyclophosphamide