Occupation and histopathology of lung cancer: A case-control study in Rosario, Argentina

Am J Ind Med. 1999 Oct;36(4):437-43. doi: 10.1002/(sici)1097-0274(199910)36:4<437::aid-ajim4>3.0.co;2-c.


Background: Male age-adjusted lung cancer mortality rate is high in Rosario City, Argentina (62.7 per 100,000).

Methods: Case-control study involving interviews with 367 male lung cancer patients and 576 controls.

Results: The histological distribution detected was: squamous cell 39%, adenocarcinoma 34%, small cell carcinoma 13%, and other or no specified cell type 14%. When comparing with the group unlikely to be exposed to occupational carcinogens, a 60% increase in risk was observed for the remaining occupations (P < 0.008). Risks were high for drivers (OR=1.9, CI: 1.1-4.0), construction (OR=2.5, CI: 1.0-5.9), and agricultural workers also (OR=1.8, CI: 1. 1-3.1). In regard to squamous cell carcinoma, increased risks were observed in the metal industry, particularly in welders (OR=2.9, CI: 1.0-10.1) and mechanics (OR=1.8, CI: 0.9-4.2). Smoking was not a substantial confounding effect.

Conclusions: Occupational exposures partly account for the high lung cancer mortality rate among male residents of Rosario City.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / epidemiology*
  • Agriculture
  • Argentina / epidemiology
  • Carcinogens / adverse effects
  • Carcinoma, Small Cell / epidemiology*
  • Carcinoma, Squamous Cell / epidemiology*
  • Case-Control Studies
  • Confidence Intervals
  • Humans
  • Lung Neoplasms / epidemiology*
  • Male
  • Metallurgy
  • Middle Aged
  • Motor Vehicles
  • Multivariate Analysis
  • Occupational Exposure
  • Occupations*
  • Odds Ratio
  • Risk Factors
  • Smoking / epidemiology
  • Welding


  • Carcinogens