Bronchodilator responsiveness in a ventilator-dependent infant with severe tracheobronchomalacia

Intensive Care Med. 1999 Jul;25(7):729-32. doi: 10.1007/s001340050937.


A neonatal case of severe, ventilator-dependent tracheobronchomalacia (TBM) is described. The extent of the malacic segment was determined by endoscopy and tracheobronchography. Additionally, relevant and ever increasing reversible peripheral airway obstruction was documented by measuring the mechanical properties of the respiratory system before and after salbutamol. With the combination of endoscopically guided aortopexy and salbutamol infusion, the infant was eventually weaned from mechanical ventilation at the age of 86 days. We speculate that in ventilator-dependent infants with severe TBM the determination of bronchodilator responsiveness may have clinical consequences.

Publication types

  • Case Reports

MeSH terms

  • Albuterol / pharmacology
  • Albuterol / therapeutic use*
  • Bronchial Diseases / complications
  • Bronchial Diseases / therapy*
  • Bronchodilator Agents / pharmacology
  • Bronchodilator Agents / therapeutic use*
  • Bronchography
  • Female
  • Humans
  • Infant, Newborn
  • Positive-Pressure Respiration
  • Respiration, Artificial
  • Respiratory Distress Syndrome, Newborn / etiology
  • Respiratory Distress Syndrome, Newborn / therapy*
  • Respiratory Mechanics / drug effects*
  • Tracheal Diseases / complications
  • Tracheal Diseases / therapy*


  • Bronchodilator Agents
  • Albuterol