Late angiographic follow-up review of surgically treated aneurysms

J Neurosurg. 1999 Sep;91(3):396-401. doi: 10.3171/jns.1999.91.3.0396.


Object: This study was undertaken to evaluate the long-term angiographic outcome of surgically treated aneurysms, which is unknown. Specifically, the incidence of recurrent aneurysms, the fate of residual necks, and the de novo formation of aneurysms were evaluated.

Methods: One hundred two patients (80 females and 22 males; mean age 49 years; range 12-78 years) harboring a total of 167 aneurysms underwent late follow-up angiography; 160 aneurysms were surgically treated. Late angiographic follow-up review was obtained at a mean of 4.4 +/- 1.6 years postsurgery (range 2.6-9.7 years). Late follow-up angiography revealed two recurrent aneurysms (1.5%) of 135 clipped aneurysms without residua. Of 12 aneurysms with known residua, there were eight "dog-ear" residua, of which two (25%) enlarged. One hemorrhage was noted, yielding a hemorrhage risk of 1.9% per year. A second subgroup with broad-based residua revealed dramatic regrowth in three of four cases. Eight de novo aneurysms were found in six patients, for an annual risk of 1.8% per year. A history of multiple aneurysms was associated with de novo aneurysm formation (p = 0.049, chi-square analysis).

Conclusions: This study confirms the long-term efficacy of aneurysm clip ligation. In addition, the authors found there is a small but significant risk of de novo aneurysm formation, particularly in patients with multiple aneurysms. Most residual aneurysm rests appear to remain stable, although a subset may enlarge or rupture. These findings support the rationale for late angiographic follow-up review in patients with aneurysms.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cerebral Angiography*
  • Chi-Square Distribution
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / physiopathology
  • Intracranial Aneurysm / surgery*
  • Ligation
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Postoperative Complications
  • Prospective Studies
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Subarachnoid Hemorrhage / etiology
  • Treatment Outcome