Allograft bone. The influence of processing on safety and performance

Orthop Clin North Am. 1999 Oct;30(4):571-81. doi: 10.1016/s0030-5898(05)70110-3.


Advances in tissue processing technology have been important for the successful use of bone allografts. The challenge is to prepare allografts that are well cleaned, sterile, and free of viruses while still preserving the natural biologic and biomechanical properties of the tissue. This article discusses how processing techniques aimed at achieving safety and sterility can affect the properties vital for graft incorporation and healing.

Publication types

  • Review

MeSH terms

  • Biology
  • Biomechanical Phenomena
  • Bone Transplantation* / pathology
  • Bone Transplantation* / physiology
  • Bone and Bones / virology
  • Graft Survival
  • Humans
  • Medical Laboratory Science
  • Safety
  • Sterilization
  • Tissue Preservation* / methods
  • Transplantation, Homologous
  • Virus Diseases / prevention & control
  • Virus Diseases / transmission
  • Wound Healing