Gene therapy for osteoinduction

Orthop Clin North Am. 1999 Oct;30(4):625-33. doi: 10.1016/s0030-5898(05)70115-2.


One application of gene therapy that holds great promise is the stimulation of bone formation. Gene therapy offers several potential advantages over other methods of osteoinduction and current research suggests that it may be a feasible treatment option for the orthopedic surgeon in the near future. This article reviews the basic concepts and strategies of gene therapy and evaluates the current research using gene therapy to induce bone formation and enhance healing.

Publication types

  • Review

MeSH terms

  • Bone Marrow Cells / cytology
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / genetics
  • Feasibility Studies
  • Genetic Therapy* / methods
  • Humans
  • Osteogenesis / genetics*
  • Transforming Growth Factor beta / genetics
  • Wound Healing / genetics


  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • Transforming Growth Factor beta