Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development

Mech Dev. 1999 Jun;84(1-2):133-8. doi: 10.1016/s0925-4773(99)00053-2.


The members of the T-box gene family share a highly conserved DNA binding domain named the T-domain, and important developmental functions. Here we report the cloning of chicken Tbr1 and of murine and chicken Tbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of expression during mouse and chick embryogenesis. Both Tbr 1 and 2 have a restricted and conserved domain of expression in the telencephalic pallium of the two species. Chick Tbr2 has a specific and dynamic expression in the gastrulating embryo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / embryology*
  • Brain / growth & development
  • Brain / metabolism
  • Chick Embryo
  • Chickens
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Developmental*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Nerve Tissue Proteins*
  • Sequence Homology, Amino Acid
  • T-Box Domain Proteins*
  • Transcription Factors / genetics


  • DNA-Binding Proteins
  • Eomes protein, mouse
  • Nerve Tissue Proteins
  • T-Box Domain Proteins
  • Tbr1 protein, mouse
  • Transcription Factors