Antimicrobial activity of xanthones from Calophyllum species, against methicillin-resistant Staphylococcus aureus (MRSA)

J Ethnopharmacol. 1999 Sep;66(3):339-42. doi: 10.1016/s0378-8741(98)00239-6.


During the past 5 years, a considerable number of known and new xanthones from the Calophyllum species of Sri Lanka have been isolated and characterized. We have investigated the antimicrobial activity of Calophyllum xanthones, with a special reference to methicillin-resistant Staphylococcus aureus (MRSA). These activity studies were carried out using the agar plate method. Calozeloxanthone, a xanthone which has been isolated from C. moonii and C. lankensis, showed the highest activity against methicillin-resistant S. aureus (MRSA) strains at a concentration of 8.3 microg/ml. Hence, calozeyloxanthone appears to hold promise as an antimicrobial agent in the treatment of infections with S. aureus, including methicillin-sensitive S. aureus (MRSA), and should be investigated further.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Microbial
  • Methicillin / pharmacology*
  • Penicillins / pharmacology
  • Plant Extracts / pharmacology*
  • Species Specificity
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / drug effects*
  • Xanthenes / pharmacology*
  • Xanthones*


  • Anti-Bacterial Agents
  • Penicillins
  • Plant Extracts
  • Xanthenes
  • Xanthones
  • calozeloxanthone
  • calozeyloxanthone
  • Methicillin