The 1998 Garrod lecture. Current and future antifungal therapy: new targets for antifungal agents

J Antimicrob Chemother. 1999 Aug;44(2):151-62. doi: 10.1093/jac/44.2.151.


Invasive fungal infections are a major problem in immunocompromised patients. The recent expansion of antifungal drug research has occurred because there is a critical need for new antifungal agents to treat these life-threatening invasive infections. The overview of the development of antifungal therapy which is provided herein reflects the increased interest in this very special area of infectious diseases. Although we have newer, less toxic, antifungal agents that are available for clinical use, their clinical efficacy in some invasive fungal infections, such as aspergillosis and fusariosis, is not optimal. Thus, intense efforts in antifungal drug discovery are still needed to develop more promising and effective antifungal agents for use in the clinical arena.

Publication types

  • Lecture
  • Review

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / classification
  • Antifungal Agents / therapeutic use*
  • Humans
  • Immunocompromised Host
  • Mycoses / drug therapy*
  • Mycoses / microbiology
  • Opportunistic Infections / drug therapy*
  • Opportunistic Infections / microbiology
  • Research


  • Antifungal Agents