Background: Retinaldehyde, the natural precursor of retinoic acid, should exert similar effects on photoaged skin.
Objective: To establish the efficacy and safety of topical retinaldehyde on photoaged skin.
Methods: Open and controlled clinical studies using image analysis of silicone skin replicas.
Results: Retinaldehyde proved efficient and safe.
Conclusion: Retinaldehyde is efficient and well tolerated for the improvement of the signs of photoaging.