[The mutational spectra of gene p53 in different types of tumors]

Tsitol Genet. 1999 May-Jun;33(3):14-20.
[Article in Russian]


The comparative analysis of the frequencies of nucleotide exchanges in mutational spectra of gene p53 (5-8 exons) between germline cancer-prone families (Li-Fraumeni syndrome), between somatic mutations in the tumors of different histogenesis and cell lines, obtained from them, was carried out. The nucleotide positions with high level of mutation events (mutational "hot spots"), typical for germline mutational spectra, tissue-specific patterns of their disappearing and appearing of new ones in solid tumors in vivo, nearly complete absence of "hot spots" in lymphomas and cell lines in vitro were revealed. The obtained results allowed to suggest, that one of the leading factor controlling hot-spots distribution in 5-8 exons of gene p53 is the specificity of cell division conditions in vivo and in vitro.

Publication types

  • Comparative Study
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence / genetics
  • Cluster Analysis
  • Exons / genetics
  • Genes, p53 / genetics*
  • Genetic Predisposition to Disease / genetics
  • Germ-Line Mutation / genetics*
  • Humans
  • Li-Fraumeni Syndrome / genetics
  • Neoplasms / genetics*
  • Tumor Cells, Cultured