Acute effect of nitric oxide on Raynaud's phenomenon in scleroderma

Lancet. 1999 Aug 28;354(9180):739. doi: 10.1016/S0140-6736(99)03557-6.

Abstract

Intra-arterial infusions of L-arginine and sodium nitroprusside significantly decreased the occurrence of laboratory-induced Raynaud's phenomenon in scleroderma patients. Raising the concentration of nitric oxide may be of therapeutic value in this population.

Publication types

  • Clinical Trial
  • Comparative Study
  • Letter
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Arginine / administration & dosage*
  • Cold Temperature
  • Female
  • Fingers / blood supply
  • Humans
  • Infusions, Intra-Arterial
  • Male
  • Middle Aged
  • Nitric Oxide / blood*
  • Nitroprusside / administration & dosage*
  • Raynaud Disease / blood
  • Raynaud Disease / drug therapy*
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / drug therapy*
  • Vasodilation / drug effects

Substances

  • Nitroprusside
  • Nitric Oxide
  • Arginine