A health-related quality of life questionnaire for multiple sclerosis patients

Acta Neurol Scand. 1999 Sep;100(3):148-55. doi: 10.1111/j.1600-0404.1999.tb00730.x.


Objective: The construction of a brief, valid and reliable HRQoL questionnaire for use in multiple sclerosis patients based on generic and disease-specific HRQoL measures.

Material and methods: The Medical Outcomes Study 36-item Short Form Health Survey (SF-36), COOP/ WONCA Charts, and Disability & Impact Profile (DIP) were used in a longitudinal study in 162 patients with multiple sclerosis.

Results: Factor analyses identified 2 underlying dimensions of HRQoL, relating to "physical functioning" and "psychological functioning". Selection of the 3 highest loading reliable scales on each factor resulted in a final questionnaire consisting of 3 scales of the SF-36 and 3 scales of the DIP. In total 40 items were selected; completion time is about 10 min.

Conclusion: The final questionnaire adequately measured 2 dimensions of HRQoL. The length of the questionnaire is acceptable for patients with MS in view of respondent burden.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Disability Evaluation
  • Female
  • Health Surveys
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / psychology*
  • Multiple Sclerosis / rehabilitation
  • Psychometrics
  • Quality of Life*
  • Reproducibility of Results
  • Self Care
  • Severity of Illness Index
  • Surveys and Questionnaires / standards*