DNA polymerase beta inhibitors from Sandoricum koetjape

J Nat Prod. 1999 Aug;62(8):1110-3. doi: 10.1021/np990104r.

Abstract

Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase beta inhibition led to the isolation of three active compounds (1-3) having IC(50) values from 20 to 36 microM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase beta with IC(50) values ranging from 16 to 36 microM.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA Polymerase beta / antagonists & inhibitors*
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Kinetics
  • Plant Epidermis / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry*
  • Wood

Substances

  • Enzyme Inhibitors
  • Plant Extracts
  • DNA Polymerase beta