Abstract
Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase beta inhibition led to the isolation of three active compounds (1-3) having IC(50) values from 20 to 36 microM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase beta with IC(50) values ranging from 16 to 36 microM.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA Polymerase beta / antagonists & inhibitors*
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Kinetics
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Plant Epidermis / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry*
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Wood
Substances
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Enzyme Inhibitors
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Plant Extracts
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DNA Polymerase beta